CSF somatostatin increase in patients with early parkinsonian syndrome
Identifieur interne : 002353 ( Main/Exploration ); précédent : 002352; suivant : 002354CSF somatostatin increase in patients with early parkinsonian syndrome
Auteurs : A. Espino [Espagne] ; M. Calopa [Espagne] ; S. Ambrosio [Espagne] ; J. Ortolà [Espagne] ; J. Peres [Espagne] ; A. Navarro [Espagne]Source :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1995-06-01.
Abstract
Summary: Somatostatin-like immunoreactivity levels (SLI) in cerebrospinal fluid (CSF) were determined in twenty-three patients with untreated parkinsonian syndrome (15 with Idiopathic Parkinson's disease (IPD) and 8 with other forms of parkinsonism) at the moment of clinical diagnosis (mean duration of disease 1.1±0.2 years), and in 26 subjects without neurological symptoms. None of the IPD patients had a diagnosis of dementia at the moment of inclusion in the study. CSF-SLI content was found to be significantly higher in patients with parkinsonian syndrome (107.9±9.8 pg/ml) than in control subjects (73.5±8.4 pg/ml). The increase was also significant when controls were compared with IPD patients. In addition, a positive correlation between SLI and homovanillic acid was found in CSF of all patients. A test of learning memory was used to evaluate the mental state of patients and a significant increase in CSF-somatostatin levels was observed in patients with Idiopathic Parkinson's disease and severe affectation of memory. These results indicate that in the early steps of untreated parkinsonian syndrome, somatostatin concentration in cerebrospinal fluid may increase, probably due to the neurodegenerative depletion of somatostatin from striatal or cortical neurons.
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DOI: 10.1007/BF02259660
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Espino</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Prínceps d'Espanya</wicri:regionArea><wicri:noRegion>Hospital Prínceps d'Espanya</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Bioquímica, Facultat d'Odontologia, C/Feixa Llarga s/n, 08907, L'Hospitalet, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Calopa, M" sort="Calopa, M" uniqKey="Calopa M" first="M." last="Calopa">M. 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Ortolà</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hormone Unit, Hospital Prínceps d'Espanya</wicri:regionArea><wicri:noRegion>Hospital Prínceps d'Espanya</wicri:noRegion></affiliation></author><author><name sortKey="Peres, J" sort="Peres, J" uniqKey="Peres J" first="J." last="Peres">J. Peres</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Prínceps d'Espanya</wicri:regionArea><wicri:noRegion>Hospital Prínceps d'Espanya</wicri:noRegion></affiliation></author><author><name sortKey="Navarro, A" sort="Navarro, A" uniqKey="Navarro A" first="A." last="Navarro">A. 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None of the IPD patients had a diagnosis of dementia at the moment of inclusion in the study. CSF-SLI content was found to be significantly higher in patients with parkinsonian syndrome (107.9±9.8 pg/ml) than in control subjects (73.5±8.4 pg/ml). The increase was also significant when controls were compared with IPD patients. In addition, a positive correlation between SLI and homovanillic acid was found in CSF of all patients. A test of learning memory was used to evaluate the mental state of patients and a significant increase in CSF-somatostatin levels was observed in patients with Idiopathic Parkinson's disease and severe affectation of memory. These results indicate that in the early steps of untreated parkinsonian syndrome, somatostatin concentration in cerebrospinal fluid may increase, probably due to the neurodegenerative depletion of somatostatin from striatal or cortical neurons.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><noRegion><name sortKey="Espino, A" sort="Espino, A" uniqKey="Espino A" first="A." last="Espino">A. Espino</name></noRegion><name sortKey="Ambrosio, S" sort="Ambrosio, S" uniqKey="Ambrosio S" first="S." last="Ambrosio">S. Ambrosio</name><name sortKey="Calopa, M" sort="Calopa, M" uniqKey="Calopa M" first="M." last="Calopa">M. Calopa</name><name sortKey="Espino, A" sort="Espino, A" uniqKey="Espino A" first="A." last="Espino">A. Espino</name><name sortKey="Navarro, A" sort="Navarro, A" uniqKey="Navarro A" first="A." last="Navarro">A. Navarro</name><name sortKey="Ortola, J" sort="Ortola, J" uniqKey="Ortola J" first="J." last="Ortolà">J. Ortolà</name><name sortKey="Peres, J" sort="Peres, J" uniqKey="Peres J" first="J." last="Peres">J. Peres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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